# nreblr.net — Clinical Research Ethics & IRB Governance Observatory

> Independent biomedical research ethics, institutional review board (IRB/REC) governance, and international clinical trial compliance repository. Preserves the historical statutory bioethics archive of Liberia NREB-LR (cited by NIH NIAID ClinRegs and the Global Health Security Index) while providing modern ICH-GCP E6(R3), Declaration of Helsinki (2024), CIOMS, and Multi-Regional Clinical Trial (ICH E17) reference frameworks.

## Core Reference Pages
- [Home & Observatory Index](https://nreblr.net/): Overview of international clinical research ethics standards, governance pillars, and historical archive.
- [REC Organization Structure & Review Pathways](https://nreblr.net/organization-structure/): Institutional review board composition, 21-member quorum rules, Full Board vs. Expedited review criteria, and interactive REC Review Pathway & Submission Checklist (fulfills NIH ClinRegs LBR-18).
- [Ethical Mandate, Risk Stratification & Biosafety Oversight](https://nreblr.net/mission-vision/): Human subjects protection principles, minimal-risk criteria, interactive Ethical Risk & ICF Compliance Checklist, and GHS Index Indicator 5.2 dual-use biosecurity framework.
- [Clinical Research Ethics & Informed Consent Standards](https://nreblr.net/ethics/): Declaration of Helsinki (2024), CIOMS 2016 guidelines, vulnerable populations, and pediatric assent standards.
- [International Trial Governance & ICH-GCP E6(R3)](https://nreblr.net/governance/): Risk-Based Quality Management (RBQM), ICH E17 multi-regional trials, sponsor/CRO oversight, and decentralized trial governance.
- [Global Health Security & Biobanking Compliance](https://nreblr.net/biosecurity/): Material Transfer Agreements (MTAs), Nagoya Protocol, pathogen genome sharing, and outbreak/PHEIC accelerated ethics review.
- [Regional Archive & Regulatory Continuity](https://nreblr.net/archive/): Historical Liberia health research statutes, PREVAIL Ebola trial governance lessons, and AVAREF regulatory harmonization.
- [About & Historical Domain Disclosure](https://nreblr.net/about/): Independent editorial governance, non-governmental archival disclaimer, and contact information.